تفاعل #4779

معادلة التفاعل

5-bromomethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

N-methylpiperazine

→

6-methyl-5-(4-methylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

المذيبات

isopropyl alcohol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 6 hours
2. 2
   أخرىAfter evaporating the solvent
3. 3
   workup.DISSOLUTIONthe residue was dissolved in chloroform
4. 4
   غسيلwashed with saturated aqueous sodium chloride
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   أخرىThe filtrate was evaporated under reduced pressure
7. 7
   غسيلeluting with chloroform
8. 8
   workup.ADDITIONThe fractions containing the object compound
9. 9
   تركيزconcentrated under reduced pressure
10. 10
    أخرىThe residue was recrystallized from diethyl ether

الإجراء التجريبي

A mixture of 5-bromomethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.5 g), N-methylpiperazine (1.17 g) in isopropyl alcohol (15 ml) was refluxed for 6 hours. After evaporating the solvent, the residue was dissolved in chloroform, washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The filtrate was evaporated under reduced pressure, and the residue was subjected to column chromatography on alumina (100 g) eluting with chloroform. The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was recrystallized from diethyl ether to give 6-methyl-5-(4-methylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine. (0.30 g).

المصدر