تفاعل #4777

معادلة التفاعل

5-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

→

5-formyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

المردود 50.3%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed for 2 hours
2. 2
   أخرىto stand to room temperature
3. 3
   ترشيحmanganese dioxide was filtered off
4. 4
   أخرىThe filtrate was evaporated in vacuo
5. 5
   أخرىthe residual precipitate was recrystallized from diethyl ether

الإجراء التجريبي

To a solution of 5-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (0.3 g) in ethyl acetate (10 ml) was added activated manganese dioxide (2.4 g) and the mixture was refluxed for 2 hours under stirring vigorously. After allowing to stand to room temperature, manganese dioxide was filtered off. The filtrate was evaporated in vacuo, and the residual precipitate was recrystallized from diethyl ether to give 5-formyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (0.15 g).

المصدر