تفاعل #4772

معادلة التفاعل

5-acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

sodium borohydride

→

5-(1-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

المردود 76.2%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was evaporated in vacuo
2. 2
   workup.ADDITIONthe residue was poured into a mixture of ethyl acetate and water
3. 3
   تجفيفThe separated organic layer was dried over magnesium sulfate
4. 4
   أخرىevaporated in vacuo
5. 5
   أخرىThe crystalline residue was recrystallized from a mixture of n-hexane and diethyl ether

الإجراء التجريبي

A mixture of 5-acetyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (3 g) and sodium borohydride (0.34 g) in methanol (110 ml) was stirred at room temperature for 4 hours. The reaction mixture was evaporated in vacuo and the residue was poured into a mixture of ethyl acetate and water. The separated organic layer was dried over magnesium sulfate and evaporated in vacuo. The crystalline residue was recrystallized from a mixture of n-hexane and diethyl ether to give a 5-(1-hydroxyethyl)-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (2.3 g).

المصدر