تفاعل #4767

معادلة التفاعل

methyl 4-methyl-2-phenyl-6-(3-nitrophenyl)-1,6-dihydro-5-pyrimidinecarboxylate

→

methyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate

المردود 67.8%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed for two hours
2. 2
   ترشيحmanganese dioxide was filtered off
3. 3
   أخرىThe filtrate was evaporated in vacuo
4. 4
   أخرىthe residual precipitate was recrystallized from diisopropyl ether (500 ml)
5. 5
   ترشيحThe crystal was filtered off
6. 6
   غسيلwashed with diisopropyl ether
7. 7
   أخرىdried in vacuo

الإجراء التجريبي

To a solution of methyl 4-methyl-2-phenyl-6-(3-nitrophenyl)-1,6-dihydro-5-pyrimidinecarboxylate (475 g) in chloroform (5 l) was added activated manganese dioxide (1.9 kg) and the mixture was refluxed for two hours with stirring vigorously. After allowing to cool to room temperature, manganese dioxide was filtered off. The filtrate was evaporated in vacuo and the residual precipitate was recrystallized from diisopropyl ether (500 ml). The crystal was filtered off, washed with diisopropyl ether and dried in vacuo to give methyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (320 g).

المصدر