تفاعل #47634

معادلة التفاعل

3-bicyclo[2.2.1]hept-2-yl-2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid methyl ester

lithium hydroxide monohydrate

hydrochloric acid

→

3-bicyclo[2.2.1]hept-2-yl-2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid

المردود 87.9%

المذيبات

tetrahydrofuran

water

ظروف التفاعل

المعالجة

1. 1
   أخرىIn a flask was placed
2. 2
   استخلاصextracted with ethyl acetate (3×20 mL)
3. 3
   تجفيفThe combined organic layers were dried over magnesium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated in vacuo

الإجراء التجريبي

In a flask was placed 3-bicyclo[2.2.1]hept-2-yl-2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid methyl ester (87 mg, 0.22 mmol) dissolved in tetrahydrofuran (3 mL). To this mixture at 25° C. was added a solution of lithium hydroxide monohydrate (19 mg, 0.44 mmol) in water (3 mL) and stirred for 1 h at 25° C. The mixture was then treated with a 1N aqueous hydrochloric acid solution to pH=2 and extracted with ethyl acetate (3×20 mL). The combined organic layers were dried over magnesium sulfate, filtered and concentrated in vacuo to afford 3-bicyclo[2.2.1]hept-2-yl-2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid (73 mg, 87%) as a yellow solid.

المصدر