تفاعل #47481

معادلة التفاعل

(S)-3-cyclohexyl-2-[4-(2,3-dichloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid methyl ester

lithium hydroxide

→

(S)-3-cyclohexyl-2-[4-(2,3-dichloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid

المردود 77.0%

المذيبات

tetrahydrofuran water

ظروف التفاعل

المعالجة

1. 1
   تركيزAfter this time, the mixture was concentrated
2. 2
   workup.ADDITIONthe reaction mixture was diluted with water
3. 3
   أخرىThe reaction mixture was acidified with 2N hydrochloric acid, during which time precipitation
4. 4
   أخرىThe precipitate was removed by filtration
5. 5
   غسيلwashed with cold water
6. 6
   أخرىdried in vacuo

الإجراء التجريبي

To a stirred solution of (S)-3-cyclohexyl-2-[4-(2,3-dichloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid methyl ester (405 mg, 0.001 mol) in tetrahydrofuran-water (3:1) was added lithium hydroxide (128 mg, 0.003 mol). The reaction mixture was stirred at 23° C. for 2 h. After this time, the mixture was concentrated and the reaction mixture was diluted with water. The reaction mixture was acidified with 2N hydrochloric acid, during which time precipitation occurred. The precipitate was removed by filtration, washed with cold water and dried in vacuo to obtain (S)-3-cyclohexyl-2-[4-(2,3-dichloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-propionic acid (0.3 g, 77%) as a yellow solid.

المصدر