تفاعل #47415

معادلة التفاعل

hydrogen peroxide

3-bromo-2-fluoro-phenylboronic acid

acetic acid

→

3-bromo-2-fluoro-phenol

المردود 89.0%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىto come to room temperature
3. 3
   أخرىThe mixture was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
5. 5
   غسيلwashed with hydrochloric acid (0.5N), water and brine
6. 6
   أخرىThe organic phase was dried
7. 7
   ترشيحfiltered
8. 8
   أخرىevaporated which

الإجراء التجريبي

To a solution of 3-bromo-2-fluoro-phenylboronic acid (25.0 g, 0.114 mol) in tetrahydrofuran (250 mL) was added glacial acetic acid (150 mL). The resulting mixture was cooled to 0° C. before hydrogen peroxide (50% aqueous solution, 25 mL) was added. The resulting mixture was allowed to come to room temperature and stirred for 24 h. The mixture was evaporated and the residue was dissolved in ethyl acetate, washed with hydrochloric acid (0.5N), water and brine. The organic phase was dried, filtered and evaporated which afforded 3-bromo-2-fluoro-phenol (19.50 g, 89%) as a brown solid.

المصدر