تفاعل #4722

معادلة التفاعل

triethylamine

phenyl isocyanide dichloride

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide

→

N-Phenyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-oxadiazole-2,5-diamine

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحSolid triethylammonium chloride is filtered off
2. 2
   تركيزthe filtrate is concentrated by evaporation under vacuum
3. 3
   أخرىthe solid residue is recrystallised from ethanol

الإجراء التجريبي

1.4 ml (10 mmol) of triethylamine and 0.7 ml (5 mmol) of phenyl isocyanide dichloride are added to 1.5 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide in 30 ml of THF and the mixture is stirred at room temperature until the reaction is quantitative. Solid triethylammonium chloride is filtered off, the filtrate is concentrated by evaporation under vacuum, and the solid residue is recrystallised from ethanol. The analytical values are summarized in Table II.

المصدر