تفاعل #47116

معادلة التفاعل

Hydrogen chloride

1-phenyl-2-(pyridin-3-yl)ethan-1,2-dione

sulfamide

→

product 497

3-(Pyridin-3-yl)-4-phenyl-1,2,5-thiadiazole-1,1-dioxide hydrochloride

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux
2. 2
   درجة الحرارةthen cooled to rt
3. 3
   أخرىThe solid that formed
4. 4
   ترشيحis filtered
5. 5
   أخرىdried

الإجراء التجريبي

Hydrogen chloride gas is bubbled into a solution of 1-phenyl-2-(pyridin-3-yl)ethan-1,2-dione (1.63 g, 7.7 mmol, J. Org. Chem., 1999, 64, 6102) and sulfamide (750 mg, 7.7 mmol) in methanol (10 mL) until the solution begins to reflux. The gas flow is turned off, and the solution stirred at 65° C. for 3 h then cooled to rt. The solid that formed is filtered and dried to give 2.06 g of the product 497. MS: m/z 272 (M++1).

المصدر