تفاعل #47098

معادلة التفاعل

2-phenoxyethan-1-ol

ethyl diazoacetate

→

product 440

المردود 82.8%

(2-Phenoxy)ethoxyacetic acid ethyl ester

المردود 82.8%

المذيبات

heptane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   أخرىThe filtrate is evaporated
3. 3
   workup.DISTILLATIONthe residue vacuum distilled

الإجراء التجريبي

To a solution of 2-phenoxyethan-1-ol (1.5 mL, 12.7 mmol) in dichloromethane (50 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (1.1 mL, 10.5 mmol). The reaction mixture is stirred at rt overnight. The reaction mixture is diluted with heptane, and filtered. The filtrate is evaporated, and the residue vacuum distilled to give 1.95 g of the product 440. 1H NMR (CDCl3) δ 7.40-7.25 (m, 2 H), 7.10-6.90 (m, 3 H), 4.30-4.15 (m, 5 H), 4.15-4.05 (m, 1 H), 4.05-3.90 (s, 2 H), 1.28 (t, 3 H)

المصدر