تفاعل #470966

معادلة التفاعل

methyl 5-hydroxynicotinate

→

methyl cis-5-hydroxypiperidine-3-carboxylate

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 3 days
2. 2
   أخرىat 70° C
3. 3
   ترشيحRh on Al2O3 catalyst was filtered off
4. 4
   تركيزthe filtrate was concentrated in vacuo

الإجراء التجريبي

A solution of methyl 5-hydroxynicotinate (1.50 g) in MeOH (30 ml) was hydrogenated (ca. 4 atm) for 3 days in a Parr low-pressure hydrogenation apparatus with a 5 wt. % Rh on Al2O3 catalyst (300 mg) at 70° C. Rh on Al2O3 catalyst was filtered off and the filtrate was concentrated in vacuo to give the crude methyl cis-5-hydroxypiperidine-3-carboxylate as a pale yellow oil.

المصدر