تفاعل #47086

معادلة التفاعل

Et2O

benzyl mercaptan

potassium carbonate

ethyl bromoacetate

→

product 402

المردود 49.9%

(Benzylsulfanyl)acetic acid ethyl ester

المردود 49.9%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   غسيلthe mixture is washed with water, brine
2. 2
   تجفيفdried (MgSO4)
3. 3
   ترشيحfiltered
4. 4
   أخرىThe filtrate is evaporated
5. 5
   workup.DISTILLATIONdistilled (130-140° C.)

الإجراء التجريبي

To a solution of benzyl mercaptan (1.18 mL, 10.0 mmol) in DMF (20 mL) is added potassium carbonate (1.51 g, 10.9 mmol) and ethyl bromoacetate (1.17 mL, 10.6 mmol), and the mixture is stirred at RT for 25 min. Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled (130-140° C.) to give 1.05 g of the product 402.

المصدر