تفاعل #47080

معادلة التفاعل

benzyl alcohol

ethyl diazoacetate

→

product 390

المردود 93.2%

Benzyloxyacetic acid ethyl ester

المردود 93.2%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONdistilled at 110° C.

الإجراء التجريبي

To a solution of benzyl alcohol (1.04 mL, 10.0 mmol) in dichloromethane (30 mL) is added rhodium (II) acetate dimer (40 mg) followed by ethyl diazoacetate (1.14 g, 10.0 mmol). The reaction mixture is stirred at RT for 20 min. The reaction mixture is rotary evaporated, and the residue is vacuum distilled at 110° C. to give 1.81 g of the product 390. 1H NMR (CDCl3) δ 7.4-7.26 (m, 5H), 4.65 (s, 2H), 4.23 (q, 2H), 4.10 (s, 2H), 1.30 (t, 3H).

المصدر