تفاعل #47078

معادلة التفاعل

chloroacetonitrile

3-fluorophenol

potassium carbonate

→

product 386

المردود 94.2%

3-Fluorophenoxyacetonitrile

المردود 94.2%

المذيبات

EtOAc

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture is cooled to RT
2. 2
   غسيلwashed with water, brine
3. 3
   تجفيفdried (MgSO4)
4. 4
   ترشيحfiltered
5. 5
   أخرىThe filtrate is evaporated
6. 6
   أخرىthe residue purified by chromatography on silica gel
7. 7
   غسيلelution with dichloromethane

الإجراء التجريبي

To a solution of 3-fluorophenol (560 mg, 5.0 mmol) in DMF (10 mL) is added potassium carbonate (828 mg, 6.0 mmol) followed by chloroacetonitrile (0.315 mL, 50.0 mmol). The reaction mixture is stirred and heated at 50° C. for 14 h. The reaction mixture is cooled to RT, diluted with EtOAc, and washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue purified by chromatography on silica gel; elution with dichloromethane gives 712 mg of the product 386.

المصدر