تفاعل #47056

معادلة التفاعل

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2-methylbenzyl chloride

→

product 227

المردود 56.0%

2-[(2-Methylbenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

المردود 56.0%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated to dryness
2. 2
   ترشيحThe insoluble material is filtered

الإجراء التجريبي

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-methylbenzyl chloride (0.204 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 174 mg of the product 227. 1H NMR (DMSO-d6) δ 11.28 (s, 2 H), 7.68 (m, 1 H), 7.55-7.20 (m, 3 H), 7.20-7.00 (m, 6 H), 7.00-6.90 (m, 4 H), 5.82 (s, 2 H), 4.81 (s, 2 H), 2.44 (s, 3 H); MS: m/z 359 (M++1).

المصدر