تفاعل #4705

معادلة التفاعل

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methylisocyanate

Ether

→

N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   أخرىthe precipitation
3. 3
   ترشيحfiltered
4. 4
   غسيلwashed with ether
5. 5
   أخرىrecrystallised from ethanol

الإجراء التجريبي

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.40 g (6 mmol) of methylisocyanate are added and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete the precipitation, and the precipitate is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

المصدر