تفاعل #470392

معادلة التفاعل

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

المردود 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

المردود 47.9%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooled to room temperature
2. 2
   استخلاصThe mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   أخرىThe solvent was evaporated
4. 4
   أخرىthe residue was purified by column chromatography

الإجراء التجريبي

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

المصدر