تفاعل #470391

معادلة التفاعل

2-phenyl-1H-benzo[d]imidazole

ethanol

→

desired product

1-(2-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was heated up
2. 2
   درجة الحرارةto reflux for 24 hours
3. 3
   ترشيحthe precipitate was collected by filtration
4. 4
   أخرىThe product was purified by column chromatography

الإجراء التجريبي

Intermediate 1 (1.5 g, 2.1 mmol) and 142-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole (2 g, 6.4 mmol) were mixed with 30 ml of ethanol in a three-neck flask under nitrogen. The mixture was heated up to reflux for 24 hours. After cooled to room temperature, the precipitate was collected by filtration. The product was purified by column chromatography using 1:2 dichloromethane and hexanes as eluent. 0.7 g of desired product was obtained after purification.

المصدر