تفاعل #470381

معادلة التفاعل

L-lysine methyl ester dihydrochloride

triethylamine

benzyloxy acetyl chloride

→

2

المردود 31.8%

2,6-Bis-(2-benzyloxy-acetylamino)-hexanoic acid methyl ester

المردود 31.8%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solids were filtered off
2. 2
   غسيلThe organic phase was washed with 5% sodium bicarbonate (2×100 mL), water (2×100 mL)
3. 3
   تجفيفdried over sodium sulphate
4. 4
   workup.DISTILLATIONdistilled
5. 5
   أخرىThe crude 2 was purified by column chromatography on silica gel

الإجراء التجريبي

To a mixture of L-lysine methyl ester dihydrochloride (50 grams, 214.4 mmol), triethylamine (131 grams, 1.294 moles) in ethyl acetate (750 mL) at room temperature was added benzyloxy acetyl chloride (120 grams, 650.4 mmol) drop wise. The mixture was further stirred at room temperature for 2 hours. The solids were filtered off. The organic phase was washed with 5% sodium bicarbonate (2×100 mL), water (2×100 mL), dried over sodium sulphate and distilled. The crude 2 was purified by column chromatography on silica gel using Benzene: Ethyl acetate (9:1) to get pure 2 (30 grams, 31.8%) as a white powder.

المصدر