تفاعل #47038

معادلة التفاعل

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2-chlorobenzyl chloride

→

product 208

المردود 32.2%

2-[(2-Chlorobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

المردود 32.2%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated to dryness
2. 2
   ترشيحThe insoluble material is filtered

الإجراء التجريبي

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-chlorobenzyl chloride (0.198 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 105 mg of the product 208. 1H NMR (DMSO-d6) δ 11.38 (s, 2 H), 7.90-7.70 (m, 1 H), 7.70-7.55 (m, 1 H), 7.55-7.35 (m, 2 H), 7.20-7.00 (m, 6 H), 7.00-6.85 (m, 4 H), 5.81 (s, 2 H), 4.88 (s, 2 H); MS: m/z 379 (M++1).

المصدر