تفاعل #470377

معادلة التفاعل

cyclen

2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester

→

product

المردود 81.3%

5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-2-(1,4,7,10-tetraazacyclododec-1-yl)pentanoic acid benzyl ester

المردود 81.3%

المذيبات

CH3CN

CH3CN

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added dropwise
2. 2
   ترشيحThe precipitate is filtered off
3. 3
   غسيلwashed thoroughly with acetonitrile

الإجراء التجريبي

55 g of cyclen base (320 mmol) are dissolved in 550 ml of CH3CN, to which 119.8 g of brominated derivative (2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester, 288 mmol) dissolved in 550 ml of CH3CN are added dropwise. The medium is stirred at ambient temperature overnight. The precipitate is filtered off and washed thoroughly with acetonitrile. 138 g of product are obtained in the form of a white powder (corrected yield 81.3%).

المصدر