تفاعل #470366

معادلة التفاعل

potassium fluoride

N-methoxymethyl-N-methylpyrrolidinium perchlorate

→

desired product

N-Methoxymethyl-N-Methylpyrrolidinium Fluoride

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was reacted at room temperature for 1.5 hours
2. 2
   أخرىwhereby the reaction was terminated
3. 3
   workup.ADDITIONWith addition of 100 ml of methanol
4. 4
   ترشيحthe reaction mixture was filtered
5. 5
   تركيزThe filtrate was concentrated
6. 6
   أخرىdried in a vacuum
7. 7
   workup.DISSOLUTIONThe residue was then dissolved in dichloromethane
8. 8
   ترشيحthe solution was again filtered with a membrane
9. 9
   ترشيحfilter
10. 10
    تركيزthe filtrate was concentrated
11. 11
    أخرىdried

الإجراء التجريبي

A 0.44 g quantity of potassium fluoride (product of Wako Pure Chemical Ind. Ltd.) was dissolved in 11 g of deionized water, and 1.74 g of N-methoxymethyl-N-methylpyrrolidinium perchlorate was added to the solution. The mixture was reacted at room temperature for 1.5 hours, whereby the reaction was terminated. With addition of 100 ml of methanol, the reaction mixture was filtered. The filtrate was concentrated and dried in a vacuum. The residue was then dissolved in dichloromethane, the solution was again filtered with a membrane filter, and the filtrate was concentrated and dried, giving 1.05 g of the desired product.

المصدر