تفاعل #47029

معادلة التفاعل

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2,4-dichlorobenzyl chloride

→

product 199

المردود 81.3%

2-[(2,4-Dichlorobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

المردود 81.3%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated to dryness
2. 2
   ترشيحThe insoluble material is filtered

الإجراء التجريبي

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2,4-dichlorobenzyl chloride (0.218 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 287 mg of the product 199. 1H NMR (DMSO-d6) δ 11.38 (s, 2 H), 7.95-7.75 (m, 2 H), 7.65-7.50 (m, 1 H), 7.20-7.00 (m, 6 H), 7.00-6.80 (m, 4 H), 5.83 (s, 2 H), 4.90 (s, 2 H); MS: m/z 413 (M++1).

المصدر