تفاعل #4701

معادلة التفاعل

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methyl isothiocyanate

Ether

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   أخرىthe precipitate formed
3. 3
   ترشيحfiltered
4. 4
   غسيلwashed with ether
5. 5
   أخرىrecrystallised from ethanol

الإجراء التجريبي

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.44 g (6 mmol) of methyl isothiocyanate are added, and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete precipitation and the precipitate formed is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

المصدر