تفاعل #46962

معادلة التفاعل

hydrochloride

2-butyl-1,3-diazaspiro[4,4]non-1-en-4-one

potassium hydroxide

4-iodobenzyl bromide

→

title compound

المردود 88.0%

2-butyl-3-(4′-iodobenzyl)-1,3-diazaspiro[4,4]non-1-en-4-one

المردود 88.0%

المذيبات

water

toluene

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture is heated
2. 2
   درجة الحرارةat reflux for 1 hr
3. 3
   أخرىthe phases are separated
4. 4
   workup.ADDITIONTo the organic phase is added 10 mL of concentrated hydrochloric acid, 100 mL
5. 5
   أخرىis evaporated at reduced pressure, 300 mL of ethyl acetate
6. 6
   workup.ADDITIONis added
7. 7
   ترشيحthe resulting solid is filtered

الإجراء التجريبي

A solution of 23.07 g (100 mmol) of the hydrochloride of 2-butyl-1,3-diazaspiro[4,4]non-1-en-4-one and 19.8 g of potassium hydroxide in 100 mL de water is added to a solution of 29.7 g (100 mmol) of 4-iodobenzyl bromide and 3.4 g (10 mmol) of tetrabutylammonium bisulphate in 30 mL of toluene, and the mixture is heated at reflux for 1 hr. After cooling to 25° C., 100 mL of water is added and the phases are separated. To the organic phase is added 10 mL of concentrated hydrochloric acid, 100 mL is evaporated at reduced pressure, 300 mL of ethyl acetate is added and the resulting solid is filtered to give 39.6 g (88%) of the title compound in the form of hydrochloride.

المصدر