تفاعل #46956

معادلة التفاعل

2-chloro-4-fluoro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-trifluoromethyl-(2H)-pyrimidin-1-yl]benzenesulfonyl isocyanate

N-methylisopropylamine

→

3-[4-Chloro-2-fluoro-5-{[isopropyl(methyl)amino]carbonylaminosulfonyl}phenyl]-1-methyl-2,4-dioxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

المذيبات

1,2-dichloroethane

1,2-dichloroethane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred overnight
2. 2
   تركيزThe reaction mixture was concentrated
3. 3
   workup.ADDITION0.5N hydrochloric acid was added
4. 4
   أخرىThe organic phase was then dried
5. 5
   أخرىthe solvent was removed

الإجراء التجريبي

With stirring, 1.0 g (2.34 mmol) of 2-chloro-4-fluoro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-trifluoromethyl-(2H)-pyrimidin-1-yl]benzenesulfonyl isocyanate in 1,2-dichloroethane was added to a solution of 0.34 g (4.68 mmol) of N-methylisopropylamine in 1,2-dichloroethane, and the mixture was stirred overnight. The reaction mixture was concentrated, the residue was taken up in methylene chloride and 0.5N hydrochloric acid was added. The organic phase was then dried and the solvent was removed. This gave 0.5 g (42% of theory) of the title compound as a colorless solid (m.p.: 145° C.).

المصدر