تفاعل #46955

معادلة التفاعل

2-chloro-4-fluoro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-trifluoromethyl-(2H)-pyrimidin-1-yl]benzenesulfonylisocyanate

benzyl alcohol

→

title compound

Benzyl{2-chloro-4-fluoro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-trifluoromethyl-(2H)-pyrimidin-1-yl]phenyl}sulfonylcarbamate

المذيبات

1,2-dichloroethane

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe reaction mixture was stirred overnight
2. 2
   أخرىRemoval of the solvent and customary purification methods

الإجراء التجريبي

With stirring, 0.6 g (1.4 mmol) of 2-chloro-4-fluoro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-trifluoromethyl-(2H)-pyrimidin-1-yl]benzenesulfonylisocyanate in 1,2-dichloroethane was added to a solution of 0.15 g (1.4 mmol) of benzyl alcohol in methylene chloride, and the reaction mixture was stirred overnight. Removal of the solvent and customary purification methods gave 0.4 g (52% of theory) of the title compound as a colorless solid (m.p.: 231-232° C.).

المصدر