تفاعل #46917

معادلة التفاعل

2,4′-dibromoacetophenone

ethyl acetoacetate

potassium carbonate

→

title compound

ethyl 2-acetyl-4-(4-bromophenyl)-4-oxobutanoate

المذيبات

2-butanone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 24 hours
2. 2
   درجة الحرارةUpon cooling
3. 3
   ترشيحthe mixture was filtered over diatomaceous earth
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by chromatography with DCM

الإجراء التجريبي

A mixture of 2,4′-dibromoacetophenone (3.0 g, 10.8 mmol), ethyl acetoacetate (1.48 mL, 10.8 mmol) and potassium carbonate (4.5 g, 32.4 mmol) were heated in 2-butanone (50 mL) at reflux for 24 hours. Upon cooling, the mixture was filtered over diatomaceous earth and concentrated. The residue was purified by chromatography with DCM to provide the title compound as an oil. 1H NMR (CDCl3) δ ppm 1.30 (3H), 2.10 (3H), 3.19 (2H), 3.75 (1H), 4.15 (2H), 7.50 (2H), 7.81 (2H); MS (ESI) m/z 326/328.

المصدر