تفاعل #46912

معادلة التفاعل

4-carbamoylphenyl 2-(4-isobutylphenyl)propanoate

3

4-(5-thioxo-5H-1,2-dithiol-3-yl)phenyl 2-(2-methoxynaphthalen-6-yl)propanoate

Lawesson reagent

→

compound 4

المردود 55.0%

4-thiocarbamoylphenyl 2-(4-isobutylphenyl)propanoate

المردود 55.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure
2. 2
   أخرىThe obtained compound was purified by a silica gel open column
3. 3
   غسيلeluted with CH2Cl2/MeOH (9.5/0.5)

الإجراء التجريبي

4-carbamoylphenyl 2-(4-isobutylphenyl)propanoate, 3 (2.48 g, 7.62 mmol) and Lawesson reagent (3.1 g, 7.62 mmol) were dissolved in 130 ml of anhydrous benzene. The reaction was warmed to 60° C. and stirred for 4 h. The solvent was removed under reduced pressure. The obtained compound was purified by a silica gel open column and eluted with CH2Cl2/MeOH (9.5/0.5) giving the pure compound 4 (1.45 g, 55% yield).

المصدر