تفاعل #468633

معادلة التفاعل

pentafluoropyridine

dimethylamine

methylene chloride

→

4-dimethylamino-2,3,5,6-tetrafluoropyridine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   غسيلwas washed with water
2. 2
   أخرىdried over basic alumina
3. 3
   أخرىThe solvent was removed in vacuo

الإجراء التجريبي

To methylene chloride (50 mL) cooled in an ice bath was added pentafluoropyridine (2.0 g, 11.8 mmol) and dimethylamine (2.97 mL of a 40% solution in water, 24 mmol). After stirring for 30 minutes the solution was washed with water, and dried over basic alumina. The solvent was removed in vacuo to give 4-dimethylamino-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 3.13 (m,6) ppm.

المصدر