تفاعل #468578

معادلة التفاعل

ditertiarybutylcarbonate

4-piperidone monohydrate hydrochloride salt

sodium hydroxide

→

N-t-butyloxycarbonyl-4-piperidone

المردود 40.0%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   درجة الحرارةunder cooling on ice
3. 3
   workup.STIRRINGthe mixture was vigorously stirred for 6 hours at room temperature
4. 4
   استخلاصThe reaction mixture was subjected to extraction with ethyl acetate
5. 5
   أخرىthe extract was evaporated to dryness under reduced pressure
6. 6
   أخرىto thereby yield a pale yellow solid
7. 7
   أخرىBy recrystallization of the solid from hexane

الإجراء التجريبي

Water (250 ml) was added to 4-piperidone monohydrate hydrochloride salt (75 g) for dissolution, and 1 N aqueous solution of sodium hydroxide (1000 ml) was added thereto. To the solution, ditertiarybutylcarbonate (120 g) was added dropwise with stirring under cooling on ice, and the mixture was vigorously stirred for 6 hours at room temperature. The reaction mixture was subjected to extraction with ethyl acetate, and the extract was evaporated to dryness under reduced pressure to thereby yield a pale yellow solid. By recrystallization of the solid from hexane, N-t-butyloxycarbonyl-4-piperidone (3) (38.9 g) was obtained in the form of white needle-shaped crystals.

المصدر