تفاعل #46810

معادلة التفاعل

toluene

Benzene-1,2-diamine

2,2,2-Trichloro-acetimidic acid methyl ester

→

2-Trichloromethyl-1H-benzoimidazole

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvents were removed under reduced pressure
2. 2
   أخرىAfter drying under reduced pressure the product
3. 3
   أخرىwas pure enough for the next reaction step

الإجراء التجريبي

To a solution of 10 g Benzene-1,2-diamine in 250 mL acetic acid, 22.8 g 2,2,2-Trichloro-acetimidic acid methyl ester were added drop wise at RT. After 2 h 500 mL toluene were added and the solvents were removed under reduced pressure. The residue was codestilled additional two times with toluene. After drying under reduced pressure the product was pure enough for the next reaction step.

المصدر