تفاعل #46808

معادلة التفاعل

water

Pyridin-4-ol

1-Fluoro-4-nitro-benzene

Cs2CO3

→

1-(4-Nitro-phenyl)-1H-pyridin-4-one

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe resulting precipitate was collected by filtration
2. 2
   أخرىto yield a bright yellow crystalline product, which
3. 3
   أخرىwas dried under reduced pressure

الإجراء التجريبي

A mixture of 10.1 g Pyridin-4-ol and 10 g 1-Fluoro-4-nitro-benzene and 46.1 g Cs2CO3 in 30 mL DMF was stirred at RT for 2 h. This solution was poured on to 300 mL of water and the resulting precipitate was collected by filtration to yield a bright yellow crystalline product, which was dried under reduced pressure. Yield: 11.2 g.

المصدر