تفاعل #46801

معادلة التفاعل

2-(2-Trichloromethyl-1H-benzoimidazole-5-sulfonyl)-ethanol

1-isopropyl-piperidine-4-ylamine-dihydrochloride

NaHCO3

→

5-(2-Hydroxy-ethanesulfonyl)-1H-benzoimidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

المذيبات

dichloromethane

THF

H2O

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with a saturated NaHCO3-solution and brine
2. 2
   تجفيفThe organic layer was dried over MgSO4
3. 3
   تركيزconcentrated

الإجراء التجريبي

360 mg (1.05 mmol) 2-(2-Trichloromethyl-1H-benzoimidazole-5-sulfonyl)-ethanol were added to a mixture of 225.4 mg (1.05 equiv.) 1-isopropyl-piperidine-4-ylamine-dihydrochloride and 880 mg (10 equiv.) NaHCO3 in 6 mL THF and 3 mL H2O and stirred vigorously for 2 h at room temperature. The reaction mixture was diluted with dichloromethane and washed with a saturated NaHCO3-solution and brine. The organic layer was dried over MgSO4 and concentrated. The obtained product was pure enough for further reactions.

المصدر