تفاعل #46787

معادلة التفاعل

5-Chloro-pyridin-2-ylamine

pyridine

bromo-acetyl bromide

→

2-Bromo-N-(5-Chloro-pyridin-2-yl)-acetamide

المذيبات

toluene

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added dropwise under ice cooling
2. 2
   أخرىAfter 2 h the precipitate was isolated by filtration
3. 3
   أخرىrecrystallized from toluene
4. 4
   أخرىto yield a white solid

الإجراء التجريبي

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.

المصدر