تفاعل #46768

معادلة التفاعل

2-bromo-phenethylamine

triethylamine

menthoyl chloride

→

oil

المردود 98.3%

2-Isopropyl-5-methyl-cyclohexanecarboylic acid [2-(2-bromo-phenyl)-ethyl]-amide

المردود 98.3%

المذيبات

CH2Cl2

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىA 100 mL round bottom flask equipped with a stir bar
2. 2
   غسيلwashed with water (3×100 mL)
3. 3
   تجفيفOrganic layer was dried over anhydrous sodium sulfate
4. 4
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

A 100 mL round bottom flask equipped with a stir bar was charged with CH2Cl2 (30 mL), 2-bromo-phenethylamine (1.0 g, 5.00 mmol) and triethylamine (684 μl, 5.05 mmol). The reaction solution was treated with menthoyl chloride (1.02 g, 5.05 mmol) in one portion and stirred at ambient temperature for 30 minutes. The reaction was diluted with CH2Cl2 (50 mL) and washed with water (3×100 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a thick oil (1.8 g). Product was used for next step without purification.

المصدر