تفاعل #46743

معادلة التفاعل

3-Imidazol-1-yl-propylamine

3,4-Dihydro-2H-pyran-2-carbaldehyde

Trimethylsilylazide

(2-Isocyano-ethyl)-dimethyl-amine

→

{(3,4-Dihydro-2H-pyran-2-yl)-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-yl]-methyl}-(3-imidazol-1-yl-propyl)-amine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter evaporation of the solvent the residue
2. 2
   أخرىwas purified with chromatographic methods

الإجراء التجريبي

3-Imidazol-1-yl-propylamine (1 mmol) and 3,4-Dihydro-2H-pyran-2-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and (2-Isocyano-ethyl)-dimethyl-amine (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

المصدر