تفاعل #46741

معادلة التفاعل

3-Imidazol-1-yl-propylamine

1H-Indole-5-carbaldehyde

Trimethylsilylazide

1-Chloro-4-isocyanomethyl-benzene

→

[[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(1H-indol-5-yl)-methyl]-(3-imidazol-1-yl-propyl)-amine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter evaporation of the solvent the residue
2. 2
   أخرىwas purified with chromatographic methods

الإجراء التجريبي

3-Imidazol-1-yl-propylamine (1 mmol) and 1H-Indole-5-carbaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Chloro-4-isocyanomethyl-benzene (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

المصدر