تفاعل #4674

معادلة التفاعل

ether

Nicotinic acid

N-hydroxysuccinimide

Dicyclohexylcarbodiimide

→

N-Nicotinoyloxysuccinimide

المردود 72.0%

المذيبات

dioxane

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe dicyclohexylurea which precipitated
2. 2
   أخرىwas removed by filtration
3. 3
   أخرىthe solvent was removed by rotary evaporation
4. 4
   أخرىThe crude product was recrystallized from ethyl acetate
5. 5
   أخرىto give light yellow crystals which
6. 6
   أخرىThe product, obtained in 72% yield (5.2 g) and melting at 129°-131° C.

الإجراء التجريبي

Nicotinic acid (4.025 g, 0.0327 mol) and N-hydroxysuccinimide (3.763 g, 0.0327 mol) were dissolved in 130 ml of dioxane. Dicyclohexylcarbodiimide (6.75 g, 0.032 mol) in 20 ml of dioxane was added. The reaction mixture was then stirred at room temperature for 3 hours. The dicyclohexylurea which precipitated was removed by filtration and the solvent was removed by rotary evaporation. The crude product was recrystallized from ethyl acetate to give light yellow crystals which were then waashed with anhydrous ether. The product, obtained in 72% yield (5.2 g) and melting at 129°-131° C., has the formula: ##STR40##

المصدر