تفاعل #46707

معادلة التفاعل

methanesulfonyl chloride

N-{5-[3-(aminomethyl)phenyl]-2,3-dihydro-1H-inden-2-yl}-2-propanesulfonamide

triethylamine

→

title compound

المردود 55.0%

N-[5-(3-{[(methylsulfonyl)amino]methyl}phenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

المردود 55.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONthe wole mix
2. 2
   workup.ADDITIONThe reaction mix
3. 3
   غسيلwas washed with 0.5M hydrochloric acid
4. 4
   أخرىthe organic layer was evaporated under reduced pressure
5. 5
   أخرىto give a brown oil which
6. 6
   أخرىwas purified by column chromatography on a 1 g SCX column
7. 7
   غسيلeluting from 0-50% ethyl acetate in 40-60° C. petroleum ether

الإجراء التجريبي

A solution of N-{5-[3-(aminomethyl)phenyl]-2,3-dihydro-1H-inden-2-yl}-2-propanesulfonamide (69 mg, 0.2 mmol) in dichloromethane (5 ml) was treated with triethylamine (40 mg, 0.4 mmol), followed by methanesulfonyl chloride (25 mg, 0.22 mmol) and the wole mix stirred at room temperature under argon for 1 h. The reaction mix was washed with 0.5M hydrochloric acid, and the organic layer was evaporated under reduced pressure to give a brown oil which was purified by column chromatography on a 1 g SCX column eluting from 0-50% ethyl acetate in 40-60° C. petroleum ether to give the title compound as a yellow oil (46 mg, 55%).

المصدر