تفاعل #46706

معادلة التفاعل

N-[5-(3-cyanophenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

lithium aluminium hydride

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title compound

المردود 100.0%

N-{5-[3-(aminomethyl)phenyl]-2,3-dihydro-1H-inden-2-yl}-2-propanesulfonamide

المردود 100.0%

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cooling bath was removed
2. 2
   workup.ADDITIONthe whole mix
3. 3
   workup.STIRRINGstirred
4. 4
   درجة الحرارةat reflux for 2 h
5. 5
   workup.ADDITIONThe reaction mix
6. 6
   أخرىquenched with water (0.8 ml), 10% NaOH (0.8 ml), and water again (1.2 ml)
7. 7
   workup.ADDITIONThe reaction mix
8. 8
   تجفيفwas dried over sodium sulphate
9. 9
   ترشيحfiltered
10. 10
    أخرىthe filtrate evaporated under reduced pressure

الإجراء التجريبي

A 1.0M solution of lithium aluminium hydride in tetrahydrofuran (8 ml) was cooled to 0° C. in an ice/methanol bath with stirring under argon. The solution was then treated dropwise with a solution of N-[5-(3-cyanophenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide (0.67 g, 1.97 mmol) in dry tetrahydrofuran (20 ml) over 15 mins. The cooling bath was removed and the whole mix stirred at reflux for 2 h. The reaction mix was allowed to cool to room temperature and quenched with water (0.8 ml), 10% NaOH (0.8 ml), and water again (1.2 ml). The reaction mix was dried over sodium sulphate, filtered and the filtrate evaporated under reduced pressure to give the title compound as a yellow oil (0.67 g, 100%).

المصدر