تفاعل #46703

ord-1b10eb3f006e4ca5903f9547e477b874

معادلة التفاعل

CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(N)c3)cc2C1
Intermediate 4
CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(N)c3)cc2C1
N-[5-(3-aminophenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
CCS(=O)(=O)Cl
ethane sulfonyl chloride
→
CCS(=O)(=O)Nc1cccc(-c2ccc3c(c2)CC(NS(=O)(=O)C(C)C)C3)c1
title compound
CCS(=O)(=O)Nc1cccc(-c2ccc3c(c2)CC(NS(=O)(=O)C(C)C)C3)c1
N-(5-{3-[(ethylsulfonyl)amino]phenyl}-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide

المتفاعلات

CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(N)c3)cc2C1
Intermediate 4
CC(C)S(=O)(=O)NC1Cc2ccc(-c3cccc(N)c3)cc2C1
N-[5-(3-aminophenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
CCS(=O)(=O)Cl
ethane sulfonyl chloride

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared from Intermediate 4 and ethane sulfonyl chloride using the method of Example 4; mass spectrum (API): Found 421 (MH−), C20H26N2O4S2 requires 422; 1H-NMR (400 MHz, CDCl3): 1.42 (9H, m), 2.98 (2H, m), 3.18 (3H, m), 3.37 (2H, m), 4.36 (2H, m), 7.21 (2H, m), 7.29 (1H, m), 7.39 (4H, m).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07741351B2uspto-grants-2010_06