تفاعل #46701

ord-88d727a6626a46cbb465620735f1087c

معادلة التفاعل

CC(C)S(=O)(=O)NC1Cc2ccc(I)cc2C1
Intermediate 2
CC(C)S(=O)(=O)NC1Cc2ccc(I)cc2C1
N-(5-iodo-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide
CC(=O)c1cccc(B(O)O)c1
(3-acetylphenyl)boronic acid
→
CC(=O)c1cccc(-c2ccc3c(c2)CC(NS(=O)(=O)C(C)C)C3)c1
title compound
CC(=O)c1cccc(-c2ccc3c(c2)CC(NS(=O)(=O)C(C)C)C3)c1
N-[5-(3-acetylphenyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

المتفاعلات

CC(C)S(=O)(=O)NC1Cc2ccc(I)cc2C1
Intermediate 2
CC(C)S(=O)(=O)NC1Cc2ccc(I)cc2C1
N-(5-iodo-2,3-dihydro-1H-inden-2-yl)-2-propanesulfonamide
CC(=O)c1cccc(B(O)O)c1
(3-acetylphenyl)boronic acid

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared from Intermediate 2 and (3-acetylphenyl)boronic acid (Sigma Aldrich Company Ltd.) using the method of Example 1; mass spectrum (API+): Found 358 (MH+), C20H23NO3S requires 357; 1H-NMR (400 MHz, CDCl3): 1.42 (6H, d, J=7 Hz), 2.66 (3H, s), 2.99 (2H, m), 3.20 (1H, m), 3.35 (2H, m), 4.29 (2H, m), 7.32 (1H, m), 7.46 (2H, m), 7.56 (1H, m), 7.76 (1H, m), 7.92 (1H, m), 8.14 (1H, m).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07741351B2uspto-grants-2010_06