تفاعل #46686

معادلة التفاعل

1-[2-(1-adamantyl)ethyl]-1-(2-methylaminoethyl)-3-[3-(4-pyridyl)propyl]urea

potassium carbonate

sodium iodide

2-chloroethyl methyl ether

→

compound

المردود 32.1%

1-[2-(1-Adamantyl)ethyl]-1-[2-[N-(2-methoxyethyl)-N-methylamino]ethyl]-3-[3-(4-pyridyl)propyl]urea

المردود 32.1%

المذيبات

water

diethyl ether

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصAfter extraction
2. 2
   غسيلthe obtained organic layer was washed with water (100 ml)
3. 3
   تجفيفa saturated aqueous sodium chloride solution (50 ml) successively, dried over anhydrous magnesium sulfate
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   أخرىThe residue was purified by silica gel column chromatography

الإجراء التجريبي

To N,N-dimethylformamide (20 ml) were added 1-[2-(1-adamantyl)ethyl]-1-(2-methylaminoethyl)-3-[3-(4-pyridyl)propyl]urea (1.50 g, 3.76 mmol), which is a free base of Compound No. 3-1, potassium carbonate (1.56 g, 11.3 mmol) and sodium iodide (1.69 g, 11.3 mmol) at room temperature, then 2-chloroethyl methyl ether (412 μl, 4.51 mmol) was added to the mixture, and the whole was heated at 80° C. and stirred overnight, then diethyl ether (50 ml) and water (100 ml) were added to the reaction mixture. After extraction, the obtained organic layer was washed with water (100 ml) and a saturated aqueous sodium chloride solution (50 ml) successively, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the target compound (552 mg, 32.1%) as a pale yellow oily matter.

المصدر