تفاعل #46680

معادلة التفاعل

1-[2-(1-adamantyl)ethyl]-1-[2-[N-(t-butoxycarbonyl)-N-methylamino]ethyl]-3-[3-(4-pyridyl)propyl]urea

hydrogen chloride

→

1-[2-(1-Adamantyl)ethyl]-1-(2-methylaminoethyl)-3-[3-(4-pyridyl)propyl]urea dihydrochloride

المذيبات

Methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىequipped with a calcium chloride tube
2. 2
   workup.STIRRINGthe whole was stirred for one day
3. 3
   تركيزconcentrated under reduced pressure
4. 4
   أخرىto give the target compound (0.30 g

الإجراء التجريبي

Methanol (4.4 ml) was added to 1-[2-(1-adamantyl)ethyl]-1-[2-[N-(t-butoxycarbonyl)-N-methylamino]ethyl]-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-26, 0.30 g, 0.60 mmol), and the mixture was stirred at room temperature in a vessel equipped with a calcium chloride tube. A 10% solution of hydrogen chloride in methanol (4.4 ml) was added to the mixture, and the whole was stirred for one day and then concentrated under reduced pressure to give the target compound (0.30 g, quantitatively) as pale yellow amorphous powder.

المصدر