تفاعل #46665

معادلة التفاعل

hydrochloric acid

diethyl 2-methyl-2-(4-pyridylmethyl)malonate

→

2-methyl-3-(4-pyridyl)propionic acid

المردود 100.3%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed overnight
2. 2
   غسيلwashed with hexane (100 ml)
3. 3
   أخرىto remove sodium hydride oil
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   ترشيحThe resulting crystals were filtered off with ethyl acetate

الإجراء التجريبي

Next, 6 N hydrochloric acid (96.8 ml, 581 mmol) was added to diethyl 2-methyl-2-(4-pyridylmethyl)malonate (17.2 g, 64.6 mmol), and the mixture was refluxed overnight. The reaction mixture was allowed to stand, then washed with hexane (100 ml) to remove sodium hydride oil contained in diethyl 2-methyl-2-(4-pyridylmethyl)malonate and concentrated under reduced pressure. The resulting crystals were filtered off with ethyl acetate to give 2-methyl-3-(4-pyridyl)propionic acid (10.7 g, 82%) as pale pink crystals.

المصدر