تفاعل #466638

معادلة التفاعل

N-methyl-N-(4-(4-(1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-(3,4-dichlorophenyl)butyl)-benzamide

2-chloroethyl ethyl ether

1,8-diazabicyclo[5.4.0]undec-7-ene

→

title compound

N-Methyl-N-(4-(4-(1-(2-ethyoxyethyl)-1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-(3,4-dichlorophenyl)butyl)benzamide

المذيبات

acetonitrile

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةHeat to reflux
2. 2
   استخلاصExtract twice with saturated aqueous solution of ammonium chloride, 5% aqueous solution of sodium bicarbonate, water, and saturated aqueous solution of sodium chloride
3. 3
   تجفيفDry the organic layer over Na2SO4
4. 4
   ترشيحfilter
5. 5
   تركيزconcentrate invacuo

الإجراء التجريبي

Combine N-methyl-N-(4-(4-(1H-benzimidazole-2-carbonyl)piperidin-1-yl)-2-(3,4-dichlorophenyl)butyl)-benzamide (1.36 mmol), 2-chloroethyl ethyl ether (0.59 g, 5.44 mmol), and 1,8-diazabicyclo[5.4.0]undec-7-ene (1.66 g, 10.9 mmol) in acetonitrile (16 mL). Heat to reflux. After 18 hours, cool to ambient temperature and dilute the reaction mixture with ethyl acetate. Extract twice with saturated aqueous solution of ammonium chloride, 5% aqueous solution of sodium bicarbonate, water, and saturated aqueous solution of sodium chloride. Dry the organic layer over Na2SO4, filter, and concentrate invacuo to give the title compound.

المصدر