تفاعل #4664

معادلة التفاعل

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-formylamino-4-oxo-1,4-dihydroquinoline-3-carboxylate

potassium carbonate

ethyl iodide

→

solid

المردود 37.7%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-formylethylamino-4-oxo-1,4-dihydroquinoline-3-carboxylate

المردود 37.7%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.WAITthe mixture is kept for 4 hours at room temperature
2. 2
   أخرىthe precipitate obtained
3. 3
   ترشيحis filtered off
4. 4
   غسيلwashed with water
5. 5
   استخلاصextracted with chloroform
6. 6
   غسيلthe extract is washed with water
7. 7
   أخرىthe organic layer is dried
8. 8
   أخرىthe solvent is evaporated off
9. 9
   أخرىthe residue is recrystallized from an ethanol/water mixture (1:1)

الإجراء التجريبي

A mixture of 1.5 g (0.005 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-1-formylamino-4-oxo-1,4-dihydroquinoline-3-carboxylate and 1.3 g (0.01 mol) of potassium carbonate in 10 ml of dimethylformamide is stirred for 3 hours at room temperature, 2.35 g (0.015 mol) of ethyl iodide are then added and the mixture is kept for 4 hours at room temperature. It is poured into a water/ice mixture, the precipitate obtained is filtered off, washed with water and extracted with chloroform, the extract is washed with water, the organic layer is dried, the solvent is evaporated off and the residue is recrystallized from an ethanol/water mixture (1:1) to give 0.7 g of a solid melting at 192°-194° C.

المصدر