تفاعل #466283

معادلة التفاعل

Ethyl piperidine-4-carboxylate

2,2-dimethylthiirane

water

→

title compound

المردود 97.0%

Ethyl 1-(2-methyl-2-sulfanylpropyl)piperidine-4-carboxylate

المردود 97.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted several times with EtOAc
2. 2
   غسيلThe combined organic extracts were washed with brine
3. 3
   تجفيفdried over anhydrous sodium sulfate
4. 4
   أخرىThe volatiles were evaporated
5. 5
   أخرىthe residue was dried under vacuum

الإجراء التجريبي

Ethyl piperidine-4-carboxylate (3.6 g, 22.9 mmol) was dissolved in benzene (5 mL), and 2,2-dimethylthiirane (5.04 g, 57.3 mmol) was added. The reaction mixture was stirred at 80° C. for 20 hours, poured into water and extracted several times with EtOAc. The combined organic extracts were washed with brine and dried over anhydrous sodium sulfate. The volatiles were evaporated and the residue was dried under vacuum to afford 5.45 g (97%) of the title compound. 1H NMR (300 MHz, CD3OD) δ 4.12 (q, J=7.1 Hz, 2H), 2.92-2.96 (d, J=11.9 Hz, 2H), 2.19-2.40 (m, 6H), 1.61-1.86 (m, 4H), 1.29 (s, 6H), 1.25 (t, J=7.1 Hz, 2H).

المصدر