تفاعل #466177

معادلة التفاعل

ethyl {4-[(2-guanidino-thiazole-4-carbonyl)-amino]-phenoxy}-acetate

hydrochloric acid

→

[4-[(2-guanidino-thiazole-4-carbonyl)- amino]-phenoxy]-acetic acid hydrochloride

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate is filtered off under suction
2. 2
   غسيلwashed with water
3. 3
   أخرىtriturated in methanol
4. 4
   ترشيحfiltered off under suction
5. 5
   أخرىdried

الإجراء التجريبي

227 mg of ethyl {4-[(2-guanidino-thiazole-4-carbonyl)-amino]-phenoxy}-acetate are stirred for 3 days at RT in 25% hydrochloric acid. The precipitate is filtered off under suction, washed with water, triturated in methanol, filtered off under suction and dried. There are obtained 165 mg of [4-[(2-guanidino-thiazole-4-carbonyl)- amino]-phenoxy]-acetic acid hydrochloride (1:1); m.p. 278° C., MS: 336 (M+H)+.

المصدر